| abstract |
The present invention relates to compounds of formula (I), their N-oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric forms having central α 2 -adrenergic receptor antagonist activity:n n n [Formula I]n n n n n n n n In the above formula,n n n Alk is C 1-6 alkanediyl;n n n n is 1 or 2;n n n X is -O-, -S-, -S (= 0)-or -S (= 0) 2- ;n n n R 1 is each independently hydrogen, halogen, C 1-6 alkyl, nitro, hydroxy or C 1--4 alkyl-oxy, and;n n n D is indole, benzisoxazole, benzisothiazole, 2H-benzopyranone, phenoxyphenyl, benzamide benzophenone or benzopyrimidinone. The present invention also relates to methods of preparation, pharmaceutical uses and compositions thereof. |