abstract |
The present invention provides an antigenic group of peptide sequences of LB1 (f) peptides of P5-type fibrin protein from various non-type Haemophilus influenzae (ntHi) strains. The present invention also provides chimeric polypeptides which carry such peptides and induce immunogenic responses to ntHi in animals, and polynucleotides encoding such peptides and polypeptides. The present invention also relates to a method for isolating said peptide or chimeric polypeptide, a method for detecting the presence of said peptide in a biological sample, and a vaccine composition for use in the treatment of Haemophilus influenzae infection. |