| abstract |
The present invention provides that compounds of formula (I) have excellent inhibitory activity on the production of inflammatory cytokines:n n n [Formula I]n n n n n n n n [In the meal,n n n A represents a pyrrole ring;n n n R 1 is an optionally substituted aryl or heteroaryl group,n n n R 2 is an optionally substituted nitrogen containing heteroaryl group,n n n R 3 is a formula —XR 4 where X is a single bond or an optionally substituted alkylene, alkenylene or alkynylene group, R 4 is a substituted cycloalkyl group, a substituted aryl group, a substituted heterocyclyl group, An optionally substituted nitrogen-containing heterocyclyl group, a substituted heteroaryl group, an optionally substituted nitrogen-containing heteroaryl group, or —NR a R b , wherein each of R a and R b is a hydrogen atom, or alkyl, alkenyl, Alkynyl, aralkyl or alkylsulfonyl group);n n n Provided that the substituents R 1 and R 3 are bonded to two atoms of the pyrrole ring adjacent to the atom of the pyrrole ring to which the substituent R 2 is bonded. |