http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20010049198-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aea5ddac9cae108a5f80101c3f50a351 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-02 |
| filingDate | 2000-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d0e0522e4f8c6c7834d1c467f24576f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ba2ab054cc36f87ceb43f948d9e0993 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8501e0b37a26a2d37321cd7ccff51602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_407bc7939161b1498570da5a83e29250 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0282e6055df483834bdf9ae7c005a040 |
| publicationDate | 2001-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20010049198-A |
| titleOfInvention | A purifying process of 4'-epi-doxorubicin |
| abstract | The present invention relates to a method for purifying 4'-epi-doxorubicin, and more particularly, after adjusting the pH in a 4′-epi-doxorubicin crude product solution, it is applied to an adsorption resin or preparative liquid chromatography. The present invention relates to a method for purifying 4′-epi-doxorubicin, including a step of selectively adsorbing epi-doxorubicin, followed by elution, concentrating the eluate with a reverse osmosis system, and crystallizing only ethanol in a concentrator.n n n According to the present invention, 4＇-epi-doxorubicin can be purified up to 99.7% in high purity, significantly improving the drug efficacy, preventing side effects caused by impurities, and also can be purified in high yield, which is very economical. It was found that there is an excellent effect. In addition, according to the purification method according to the present invention, by concentrating rapidly by the reverse osmosis membrane, and at a low temperature it was possible to prevent denaturation of the material by heat, and crystallization only with ethanol can prevent side effects due to toxic residual solvent, etc. I could see that. In addition, since the resin used in the present invention can be reused by repeated washing with an organic solvent, it can be seen that it is more economical. |
| priorityDate | 1999-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.