| abstract |
In the presence of the medicament, the present invention provides a Smad protein or a DNA binding fragment thereof and the sequence 5'WXYCAGACZ3 ', wherein W is A or G, X is G or T, Y is C, A, G or T, and Z Is A or C) or a gene regulation by one or more Smad proteins and TGFβ or activin, comprising detecting or analyzing the extent or result of binding or transcriptional activity between the double stranded oligonucleotides comprising the functional equivalents thereof; A method of screening a therapeutic agent for use in combating associated diseases. Also described are therapeutic agents identified by this method and their use in combating diseases associated with abnormal expression of Smad-mediated TGFβ-inducing genes. |