http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20010032879-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 1998-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20010032879-A |
| titleOfInvention | Grafted copolymers as gene carriers |
| abstract | Non-toxic, multifactor gene carriers used to deliver a selected nucleic acid to a host consist of a fused copolymer with a linear amphiphilic subpolymer fused to a polycationic main polymer. Amphiphilic main polymers form complexes with nucleic acids by electrostatic interaction. Amphiphilic oligomers reduce the toxicity of polycationics and increase solubility. The molar ratio of the oligomer is adjusted to optimize transfection efficiency. Similarly, the ratio of nucleic acid to copolymer is adjusted to optimize efficiency. The composition is used in a method for transforming a host cell with a selected nucleic acid. Fused copolymers of polyethylene glycol and poly-L-lysine (PEG-g-PLL) are particularly efficient, so that maximum gene expression can be obtained within 24 hours, and the expression lasts more than 96 hours. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101357899-B1 |
| priorityDate | 1997-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 686.