| abstract |
The present invention relates to compounds of formula (I), tautomers, optical isomers, pharmaceutically acceptable salts and prodrugs thereof, as well as methods for their preparation and their use as medicaments:n n n Formula In n n n n n n n Wheren n n R 1 , R 2 , R 3 and X may be the same or different,n n n R 1 and R 2 represent hydrogen, amino acid, peptidyl, alkyl or aryl residues,n n n R 3 represents a hydroxy, lower alkoxy, or —NR 31 R 32 wherein R 31 and R 32 independently represent a hydrogen, amino acid, peptidyl, alkyl or aryl moiety;n n n X represents an amino acid or peptide,n n n R 4 represents hydrogen, hydroxy, amino or C 1 -C 4 alkyl,n n n m represents a number from 0 to 5,n n n R 5 represents an optionally substituted saturated or unsaturated monocyclic or bicyclic moiety which may contain one or more heteroatoms, and a C 1 -C 11 alkyl group which may have substituents or intermittent heteroatoms. |