| abstract |
Crosslinked particles useful for the delivery of a medicament are provided.n n n The particles comprise at least one polymeric compound and a spacer compound, wherein the polymeric compound and the spacer compound each comprise a carboxyl, hydrazyl, amino and / or thiol group. The particles are crosslinked via covalent bonds of reactive groups on the polymer and the spacer, respectively. Disclosed is a composition comprising a medicament contained in a particle. Methods of preparing the particles, methods of encapsulating the drug in the particles, and methods of using the particles for sustained release of the drug in a patient are also provided. |