| abstract |
The present invention provides a compound of Formula 1, the compound has use as a tyrosine kinase inhibitor for the treatment of certain kidney diseases such as cancer and polycystic kidney disease:n n n Formula 1n n n n n n n n In the above formulan n n X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or a substituted or unsubstituted phenyl ring as described in claim 1,n n n R 1 , R 3 and R 4 are selected from the group described in claim 1,n n n R 2 is selected from the various unsaturated acyl groups described in claim 1. |