| abstract |
The present invention provides compositions and methods for improving the various effects of UVA and UVB light from the sun. This composition comprises components that prevent aging by light from MED and sub-MED light, such as retinoids, certain other compounds (eg N-acetylcysteine, 2-furyldioxime and vitamin C) and other MMPs as optional ingredients. Inhibitors such as tetracycline and / or compounds that inhibit the P-450-mediated metabolism of retinoids such as ketoconazole and other azole compounds. In this method, the composition is applied before exposure to the sun; Depending on the components used in the composition, the application should be carried out 7 to 48 hours before exposure. Compounds that prevent erythema (skin redness, sunburn) do not necessarily protect against UV-mediated elevations of MMP levels; similarly, compounds that prevent UV-mediated elevations of MMP levels and activity are not necessarily protected. It is also not effective against UV-induced erythema. |