http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20010006479-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-76 |
| filingDate | 1998-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20010006479-A |
| titleOfInvention | Process and Intermediates for the Preparation of 4'-Trifluoromethyl-Biphenyl-2-Carboxylic Acid (1,2,3,4-Tetrahydro-Isoquinolin-6-Yl)-Amide |
| abstract | The present invention provides an improved process for the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4-tetrahydro-isoquinolin-6-yl) -amide of formula (I) And intermediates. Compound I is useful as an inhibitor of microzomal triglyceride transporter protein and / or apofatty protein B (apopoB) secretion, and thus is useful for the prevention and treatment of atherosclerosis and its clinical sequelae that lower serum lipids and related diseases. 4'-trifluoromethyl-biphenyl-2-carboxylic acid of II [2- (1H- [1,2,4-triazol-3-ylmethyl)]-(1,2,3,4- Useful for the preparation of tetrahydro-isoquinolin-6-yl) -amides. The invention is also selected from formula A-CHR 1 R 2 , wherein A is a group of formula XII and R 1 is H and OR 3 , wherein R 3 is hydrogen or (C 1 -C 6 ) alkyl R 2 is selected from OR 3 , -CH 2 -NH 2. (R 5 H) m or -CH 2 -NO 2 , or together they form a = O or = CH-NO 2 group, provided that R 1 And when R 2 are each an OR 3 group, these two R 3 are all identically related to a compound of (C 1 -C 6 ) alkyl group).n n n <Formula XII> |
| priorityDate | 1997-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.