http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20010006047-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4741 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 |
| filingDate | 1998-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20010006047-A |
| titleOfInvention | Substituted 3-cyano quinolines |
| abstract | The present invention provides a compound of formula 1 that is an inhibitor of protein tyrosine kinase.n n n Formula 1n n n n n n n n Wheren n n X is cycloalkyl, which may be optionally substituted, or is a pyridinyl, pyrimidinyl or phenyl ring, wherein the pyridinyl, pyrimidinyl or phenyl ring may be optionally substituted;n n n n is 0 or 1;n n n Y is -NH-, -O-, -S- or -NR-;n n n R is alkyl of 1 to 6 carbon atoms;n n n R 1 , R 2 , R 3 and R 4 are each independently hydrogen, halogen, alkyl, alkenyl, alkynyl, alkenyloxy, alkynyloxy, hydroxymethyl, halomethyl, alkanoyloxy, alkenoyloxy , Alkinoyloxy, alkanoyloxymethyl, alkenoyloxymethyl, alkinoyloxymethyl, alkoxymethyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido, alkenylsulfonamido, alkoxy Nilsulfonamido, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy, carboalkyl, phenoxy, phenyl, thiophenoxy, benzyl, amino, hydroxyamino, alkoxyamino, alkylamino, Dialkylamino, aminoalkyl, 7-N-alkylaminoalkyl, N, N-dialkylaminoalkyl, phenylamino, benzylamino,n n n n n n n n n n n n n ego,n n n R 5 is optionally substituted alkyl or optionally substituted phenyl;n n n R 6 is hydrogen, alkyl or alkenyl;n n n R 7 is chloro or bromo;n n n R 8 is hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N, N-dialkylaminoalkyl, N-cycloalkylaminoalkyl, N-cycloalkyl-N-alkylaminoalkyl, N, N-dicycloalkyl Aminoalkyl, morpholino-N-alkyl of alkyl group, piperidino-N-alkyl of alkyl group, N-alkyl-piperidino-N-alkyl of alkyl group, azacycloalkyl-N-alkyl, hydroxy Alkyl, alkoxyalkyl, carboxy, carboalkoxy, phenyl, carboalkyl, chloro, fluoro or bromo;n n n Z is amino, hydroxy, alkoxy, alkylamino, dialkylamino, morpholino, piperazino, N-alkylpiperazino or pyrrolidino;n n n m is 1 to 4;n n n q is 1 to 3;n n n p is 0 to 3;n n n Substituents R 1 , R 2 , R 3 or R 4 on adjacent carbon atoms may together be a divalent radical -OC (R 8 ) 2 -O-,n n n Provided that when Y is -NH-, R 1 , R 2 , R 3 and R 4 are hydrogen and n is 0, then X is not 2-methylphenyl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140009418-A |
| priorityDate | 1997-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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