| abstract |
Compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Q are as defined above may be used for arthritis, cancer, tissue ulcers, macular degeneration, Selected from the group consisting of stenosis, periodontal disease, epidermal bleb, scleritis, other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock, and other diseases involving tumor necrosis factor (TNF) production It is useful for treating symptoms. In addition, the present invention may be used in combination with standard nonsteroidal anti-inflammatory drugs (NSAID's) and analgesics or in the treatment of cancer, such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids ( (For example, vincristine). |