| abstract |
The present invention provides a method, combinations and preparations thereof, for controlling secretions in and around the eye of a patient by administering purine receptor agonists such as certain uridine, adenine or cytidine triphosphates as well as other nucleoside phosphate compounds As for the method,n n n The method utilizes uridine 5'-triphosphate [UTP], dinucleotides, cytidine 5'-triphosphate [CTP], adenosine 5'-triphosphate in an amount effective to promote tear secretion and improve drainage of tear tissue. Administering purine receptor agonists such as [ATP] or pharmaceutically available analogs and derivatives thereof to the subject's eye surface,n n n Methods of administering pharmaceutical formulations include topical administration via liquids, gels, creams or contact lenses or selective release membranes; Or inhalation by nasal drop or spray, nebulizer or other device, oral administration by oral form (liquid or pill), by injectable intraocular or suppository form. |