| abstract |
The present invention relates to novel analogs of camptothecin and in particular the formula 5-ethyl-9,10-difluoro-4,5-dihydro-5-hydroxy-12- (4-methyl piperidinomethyl) -1H -Oxepino [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,15 (4H, 13H) -dione; 5-ethyl-12-diethylaminomethyl-9-fluoro-4,5-dihydro-5-hydroxy-10-methyl-lH-oxepino [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,15 (4H, 13H) -dione; 5-ethyl-9-fluoro-4,5-dihydro-5-hydroxy-10-methyl-12- (4-methylpiperidinomethyl) -1H-oxepino [3 ', 4': 6, 7] relates to a compound of indolinino [1,2-b] quinoline-3,15 (4H, 13H) -dione. The invention also relates to their use as medicaments, pharmaceutical compositions containing them and their use in the preparation of antitumor drugs, antiviral drugs or antiparasitic drugs. |