| abstract |
The present invention provides the hexapeptide component S and the C-terminal β-aminoalcohol residue Z bonded to the component S by an amide bond, wherein β-aminoalcohol Z is -NR-CH (Q) -CH 2 OH, Q is (CH 2 ) n -NH-A, n is 1-6 and A is H or -C (= NH) NH 2 , R is CH 3 or C 2 H 5 , component S is X is D-aromatic α -Amino acids and Y relate to heptapeptide analogs or pharmaceutically acceptable salts thereof which contain aliphatic α-amino acids and have oxytocin antagonistic activity. Also their synthesis; Pharmaceutical compositions containing these homologues; Synthesis of such compositions; Disclosed is a method of controlling uterine contraction. |