| abstract |
The present invention relates to a diaryl-3 (2H) furanone derivative represented by the following general formula (I) and a pharmaceutically acceptable salt thereof, and a cyclooxyge containing an effective amount thereof Naze-2 inhibitors (cyclooxygenase-2 inhibitor) composition.n n n n n n n n n n Wheren n n X is CH 3 S, CH 3 SO or CH 3 SO 2 ,n n n Y is O or S,n n n A is hydrogen, benzo [b] thienyl, 1-naphthyl, 2-naphthyl, benzofuranyl, furanyl or a substituent having the following structural formula.n n n n n n n n Wherein R 1 to 5 are the same or different, hydrogen, halogen, lower alkyl having 1 to 5 carbon atoms, haloalkyl, alkoxy, haloalkoxy, hydroxy, hydroxyalkyl, nitro, nitrile, azido, methylenedi Oxy, phenyl, lower alkyl thio having 1 to 5 carbon atoms, lower alkyl sulfonyl having 1 to 5 carbon atoms, CO 2 R 6 , COR 6 or NR 7 R 8 .n n n Wherein R 6 is hydrogen or a lower alkyl group having 1 to 5 carbon atoms,n n n R 7-8 are the same or different from each other and are a hydrogen, methyl, ethyl or acetyl group.n n n n n n n n In the above formula,n n n R 9 is hydrogen or a methyl group.n n n n n n n n In the above formula,n n n R 10 is hydrogen or a methyl group. |