http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20000065865-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b3be70086419df7430dcf0abc1da93 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-00 |
| filingDate | 1999-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dd2afee69efe6544c47e7c81416b60e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f7f0f4e53727b61c9f44bb16cdb9b8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53e779d20099b2305458f19a660324ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c27a12a7295e1b93a8e1f74305e95d4 |
| publicationDate | 2000-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20000065865-A |
| titleOfInvention | 4,5-Diamino pyrimidine derivatives and methods for producing said compound |
| abstract | The present invention provides novel 4,5-diamino pyrimidine derivatives of the following general formula (I) having inhibitory action against cyclic guanosine 3 ', 5'-monophosphate phosphodiesterase and physiologically acceptable thereof To esters that are susceptible to salts, solvates or metabolic conversions:n n n (I)n n n Wherein X is a bond, C 1-4 alkylene, C 1-4 alkyleneoxy, C 1-4 alkoxyphenyl or phenyl (C 1-4 ) alkylene; Y is a bond or C 1-2 alkyl; R 1 is (iii) phenyl unsubstituted or substituted with one or two groups selected from the group consisting of halogen, nitro, hydroxy, C 1-6 alkyl and C 1-4 alkoxy, (ii) halogen, nitro, hydroxy , 5 to 15 membered side chain or heterocyclic compound substituted with one or two groups selected from the group consisting of C 1-6 alkyl and halogen C 1-4 alkoxy and containing one or two atoms selected from nitrogen and oxygen, (Iii) C 4-10 carbocyclic cyclic compounds or (iii) hydroxy (C 1-4 ) alkoxy; R 2 is selected from the group consisting of (i) hydroxy, halogen, nitro, hydroxy (C 1-5 ) alkyl, C 1-6 alkyl, C 3-6 alkenyl and C 1-4 alkoxy 5- to 6-membered heterocyclic compounds substituted with groups and containing 1 to 4 nitrogen atoms or (ii) hydroxy, halogen, nitro, hydroxy (C 1-5 ) alkyl, C 1-6 alkyl, C 3- A 5-15 membered heterocyclic compound substituted with one or two groups selected from the group consisting of 6 alkenyl and C 1-4 alkoxy and containing one nitrogen atom and optionally containing one oxygen or sulfur atom; R 3 is hydrogen, or Is; R 4 and R 5 are each independently substituted with one or two groups selected from the group consisting of amine, halogen, carboxy, C 1-6 alkyl, phenyl, C 1-4 alkoxy and C 1-4 alkoxycarbonyl And 5 to 6 membered heterocyclic compounds containing 2 to 4 nitrogen atoms or (ii) amine, halogen, carboxy, C 1-6 alkyl, phenyl, C 1-4 alkoxy and C 1-4 alkoxycarbonyl And a 5 to 15 membered heterocyclic compound substituted with one or two groups selected from the group consisting of and containing one or two atoms selected from nitrogen, oxygen and sulfur. The invention also relates to a process for the preparation of compound (I). |
| priorityDate | 1999-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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