| abstract |
Of compounds of formula (I) and pharmaceutically acceptable salts thereofn n n [Formula I]n n n n n n n n In which A is sulfonyl or carbonyl; R 1 is optionally substituted aryl, optionally substituted heterocyclic group, optionally substituted lower alkyl or optionally substituted lower alkenyl; R 2 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl or optionally substituted heterocyclic group; R 3 is optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted aryloxy, optionally substituted lower alkenyl, optionally substituted aryl, optionally substituted heterocyclic group or optionally substituted amino; R 4 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl or optionally substituted heterocyclic group; R 5 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl or optionally substituted heterocyclic group; R 10 is hydroxy or protected hydroxy. The compounds of the present invention are useful as medicaments for the prophylactic and therapeutic treatment of MMP- or TNFα-mediated diseases. |