http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20000052856-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1996-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ce528588d19a6aad057228defca753b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91a31ca309f5bc32447aaed5c7317a75 |
| publicationDate | 2000-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20000052856-A |
| titleOfInvention | Substituted arylalkylamines as neurokinin antagonists |
| abstract | The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof.n n n Formula In n n n n n n n In the above formula,n n n A 1 is -CH 2 R 6 , -OR 6 , -N (R 6 ) (R 7 ), -S (O) e R 13 ,-(C (R 6 ) (R 7 )) 1-6 -OR 6 ,-(C (R 6 ) (R 7 )) 1-6 -N (R 6 ) (R 7 ) or-(C (R 6 ) (R 7 )) 1-6 -S (O) e R 13 , A 2 is H, or A 1 and A 2 together are = O, = C (R 6 ) (R 7 ), = NOR 6 or = S;n n n Q is phenyl, naphthyl, -SR 6 , -N (R 6 ) (R 7 ), -OR 6 or heteroaryl;n n n T is H, aryl, heterocycloalkyl, heteroaryl, cycloalkyl or bridged cycloalkyl;n n n b is 0, 1 or 2;n n n b 1 is 1 or 2;n n n X is a bond, -C (O)-, -O-, -NR 6- , -S (O) e- , -N (R 6 ) C (O)-, -C (O) N (R 6 ) -, -OC (O) NR 6- , -OC (= S) NR 6- , -N (R 6 ) C (= S) O-, -C (= NOR 6 )-, -S (O) 2 N (R 6 ) —, —N (R 6 ) S (O) 2 —, —N (R 6 ) C (O) O— or —OC (O) —;n n n R 6 , R 7 , R 8a and R 13 are H, alkyl, hydroxyalkyl, alkoxy alkyl, phenyl or benzyl, or R 6 and R 7 together with the nitrogen atom to which they are attached may form a ring;n n n R 9 and R 9a are independently R 6 and -OR 6 ;n n n Z is an optionally substituted compound of Formula II,n n n n n n n n n n here,n n n g is 0 to 3;n n n h is 1 to 4, provided that the sum of h and g is 1 to 7;n n n Wherein aryl, phenyl, benzyl, naphthyl, heterocycloalkyl and heteroaryl groups are optionally substituted.n n n The present invention also relates to methods of treating asthma, cough, bronchiectasis, inflammatory diseases and gastrointestinal diseases using the compounds and pharmaceutical compositions containing the compounds. |
| priorityDate | 1996-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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