| abstract |
Bis (acridincarboxamide) or bis (phenazinecarboxamide) derivatives of the present invention or pharmaceutically acceptable acid addition salts or N-oxides thereof, which have activity as antitumor and antibacterial agents :n n n Formula In n n n n n n n Wheren n n Each X may be the same or different in a given molecule and is -CH = or -N =;n n n R 1 to R 4 may be the same or different, respectively, H, C 1 -C 4 alkyl, OH, SH, NH 2 , C 1 -C 4 alkoxy, aryloxy, NHR, N (R) 2 , SR or SO 2 R (where R is C 1 -C 4 alkyl, CF 3 , NO 2 or halogen) or R 1 and R 2 together form a methylenedioxy group;n n n R 5 and R 6 may each be the same or different and are H or C 1 -C 4 alkyl;n n n Z is (CH 2 ) n , (CH 2 ) n O (CH 2 ) n , (CH 2 ) n N (R 7 ) (CH 2 ) n , (CH 2 ) n N (R 7 ) (CH 2 ) m N (R 7 ) (CH 2 ) n or (CH 2 ) n N (CH 2 CH 2 ) 2 N (CH 2 ) n where R 7 is H or C 1 -C 4 alkyl, and n and m are Same or different, each being an integer of 1 to 4). |