| abstract |
External topical anesthetics of the present invention comprise (a) an active ingredient selected from lidocaine, prilocaine and pharmaceutically acceptable salts thereof, (b) transdermal absorption promoter, (c) ethanol and / or isopropyl alcohol and (d) Water is prepared by mixing so that the mixing ratio of ethanol and / or isopropyl alcohol to water is preferably 0.5 to 1.2 by weight and the pH is preferably adjusted to 6.0 to 8.5. Therefore, an external transdermal absorption type local anesthetic is provided, which is conveniently used in application and exfoliation, can be applied to a wide range of skin surfaces, and has excellent stability as well as excellent transdermal absorption and fastness. |