http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20000036104-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 |
| filingDate | 1997-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edf3081b35a951e03e9c2d47a6cc2458 |
| publicationDate | 2000-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20000036104-A |
| titleOfInvention | Novel tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase |
| abstract | The present invention relates to a novel tricyclic compound of formula 1.0 or a pharmaceutically acceptable salt or solvate thereof.n n n Formula 1.0n n n n n n n n In the above formulan n n one of a, b, c and d is N or NR 9, where R 9 is O—, —CH 3 or — (CH 2 ) n CO 2 H, n is 1 to 3; a, b, the remainder of groups c and d is CR 1 or CR 2 ;n n n a, b, c and d are each independently selected from CR 1 or CR 2 ;n n n R 1 and R 2 are each independently H, halo, -CF 3 , -OR 10 , -COR 10 , -SR 10 , -S (O) t R 11 (where t is 0, 1 or 2), -SCN, -N (R 10 ) 2 , -NR 10 R 11 , -NO 2 , -OC (O) R 10 , -CO 2 R 10 , -OCO 2 R 11 , -CN, -NHC (O) R 10 , -NHSO 2 R 10 , -CONHR 10 , -CONHCH 2 CH 2 OH, -NR 10 COOR 11 , -SR 11 C (O) OR 11 , -SR 11 N (R 75 ) 2 ;n n n n is 0 (zero), 1, 2, 3, 4, 5 or 6;n n n T is -CO-, -SO-, -SO 2- , or -CR 30 R 31- ;n n n Z is alkyl, aryl, aralkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -OR 40 , -SR 40 , -CR 40 R 42 , -NR 40 R 42 , and Compounds of formula (i), (ii), (iii), (iv), (v) and (v): (i), (ii), (iii), (iv), (v) and (vi)n n n Also described herein are pharmaceutical compositions that are inhibitors of the enzyme farnesyl protein transferase. Also described herein are methods of inhibiting abnormal growth of cells by inhibiting Ras function. The method comprises administering a novel tricyclic compound of the invention to a biological system. In particular, the method inhibits abnormal growth of cells in mammals such as humans. |
| priorityDate | 1996-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 253.