| abstract |
Estratriene derivatives represented by the formula (I) have excellent estrone sulfatase inhibitory activity, and are used for the prevention and treatment of diseases caused by estrogens, such as cancer, uterine cancer, ovarian cancer, endometriosis, uterine adenomyosis and mammary gland. It is useful.n n n [Formula I]n n n n n n n n Wherein one of A and B is C═O or CH 2 and the other is O or NH; R is —SO 2 NR 1 R 2 or —PO (OM) 2 , wherein R 1 and R 2 Are each independently a hydrogen atom or a lower alkyl group, M is a hydrogen atom or an alkali metal; provided that when one of A and B is NH, the other is C = O.) |