| abstract |
The present invention provides naphthyl compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof, intermediates, compositions and methods of use.n n n <Formula I>n n n n n n n n Wherein R 1 is —H, —OH, —O (C 1 -C 4 alkyl), —OCOAr (where Ar is phenyl or substituted phenyl), —O (CO) OAr, wherein Ar Is phenyl or substituted phenyl), -OCO (C 1 -C 6 alkyl), -O (CO) O (C 1 -C 6 alkyl), or -OSO 2 (C 4 -C 6 alkyl); R 2 is —H, —F, —Cl, —OH, —O (C 1 -C 4 alkyl), —OCOAr (where Ar is phenyl or substituted phenyl), —O (CO) OAr (here Wherein Ar is phenyl or substituted phenyl), -OCO (C 1 -C 6 alkyl), -O (CO) O (C 1 -C 6 alkyl), or -OSO 2 (C 4 -C 6 alkyl) Is; R 3 and R 4 are independently —H, —F, —Cl, —CH 3 , —OH, —O (C 1 -C 4 alkyl), —OCOAr, wherein Ar is phenyl or substituted phenyl , -OCO (C 1 -C 6 alkyl), -O (CO) O (C 1 -C 6 alkyl), or -OSO 2 (C 4 -C 6 alkyl), provided that R 3 and R 4 are both Not all hydrogen; n is 2 or 3; R 5 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino or 1-hexamethyleneimino to be. |