| abstract |
The present invention relates to compounds which are useful as inhibitors of matrix metalloproteases and are effective for treating conditions characterized by excessive activity of such enzymes. Specifically, the present invention relates to a compound having a structure according to formula (I), a stereoisomer or enantiomer thereof, or a pharmaceutically acceptable salt thereof, or an in vivo degradable alkoxyamide, ester acyloxyamide, imide or derivative thereof It is about. Also disclosed are compounds, pharmaceutical compositions, and methods of treating diseases characterized by matrix metalloprotease activity using these compounds or pharmaceutical compositions containing these compounds.n n n [Formula I]n n n n n n n n Wherein R 1 , R 2 , R 3 and R 4 are described in the claims. |