| abstract |
Compounds of formula (I) or pharmaceutically acceptable salts thereof are inhibitors of dopamine synthesis and release useful for treating schizophrenia, Parkinson's disease, Gildra Tourette syndrome, alcoholism, cocaine poisoning and addiction to similar drugs; They also have an affinity for the 5HT 1A receptor, which is characterized by its usefulness in the treatment of diseases caused by disorders of the seratonin-functional system, such as anxiety, stress, depression, sexual dysfunction and sleep disorders.n n n Formula In n n n n n n n Wheren n n R 1 is hydrogen, alkyl, cycloalkylalkyl, arylalkyl, (haloaryl) alkyl, (alkoxy-aryl) alkyl, thienylmethyl, furanylmethyl, pyridinylmethyl, alkylphenyl, 4-fluoro-butyrophenone Or 6-fluoro-1,2-benzisoxazol-yl-propyl;n n n X is hydrogen, halogen, cyano, alkyl, acetyl, trifluoroacetyl, trifluoromethyl or formyl;n n n Y is hydrogen, halogen, alkoxy or alkyl. |