| abstract |
Compounds of formula (I) or pharmaceutically acceptable salts thereof are dopamine synthesis and release useful for treating schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcoholism, cocaine addiction and similar drug addiction It is an inhibitor of.n n n Formula In n n n n n n n In Formula I above,n n n Y is hydrogen, halogen or lower alkoxy,n n n R 1 is hydrogen, lower alkyl or aryl (lower) alkyl,n n n R 2 is hydrogen, lower alkyl or — (CH 2 ) n X p Ar where X is oxygen or carbonyl, Ar is cycloalkyl, aryl or arylaryl, oxindolinyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thiooxobenzimidazolyl, n is one of integers from 1 to 6, p is an integer of 0 or 1), orn n n R 1 and R 2 together with the nitrogen atom to which they are attached form 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl. |