http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20000035794-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 |
| filingDate | 1997-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffa1d255b18e03f81af541ef85793cec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce90784b64c9b58af217f3e49eaa0ac5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74e2ef73e0bb77fcfe96a310bc7bc3e0 |
| publicationDate | 2000-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20000035794-A |
| titleOfInvention | Synthesis of cisapride |
| abstract | The present invention is directed to reductive amination of 1- [3- (4-fluorophenoxy) -propyl] -3-methoxy-4-piperidinone under hydrogen in a suitable reaction-inert solvent in the presence of benzylamine. Obtain 1- [3- (4-fluorophenoxy) -propyl] -3-methoxy-4-piperidinamine having a cis / trans ratio of about 93/7, and the obtained compound is a suitable inorganic acid in a suitable solvent. And converted to its acid addition salt and crystallized, and then converted to its free base by treatment with an appropriate base to give 1- [3- (4-fluorophenoxy) -propyl]-with a cis / trans ratio of at least 98/2. The amount of cis-stereoisomers is increased by obtaining 3-methoxy-4-piperidinamine, followed by cis-1- [3- (4-fluorophenoxy) -propyl] -3-methoxy 4-piperidinamine is reacted with ethyl chloroformate and 4-amino-5-chloro-2-methoxy-benzoic acid in a reaction-inert solvent And the characterized in that the obtained relates to a novel process for preparing acid addition salts and pharmaceutically acceptable cisapride. |
| priorityDate | 1996-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.