http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20000031977-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9673d6f44e8fcbc4593ee374bd4b0bf2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1998-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdfcdd96830391c8db0c08b7695caaa0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff95572879e5a3a839874bb66d729448 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b35db4f6f25ee83891d38258ce6088cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2ea1fb232271dee204925884064333d |
| publicationDate | 2000-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20000031977-A |
| titleOfInvention | Inhibition of Cancer Cell Proliferation Using Berberubin |
| abstract | The present invention is an isoquinoline alkaloid compound extracted from Berberis vulgaris L., which not only promotes DNA cleavage mediated by topoisomerase II but also catalyzes topoisomerase II. It relates to a method of inhibiting the proliferation of cancer cells using berberubin to inhibit the activity. Berberubin is a reversible topoisomerase II-mediated DNA cleavage / reconnection reaction that traps topoisomerase II by trapping nicked circular DNA that is an intermediate between linear and circular DNA. Inhibition of DNA recombination, and directly inhibits the enzyme activity of topoisomerase even in the step before formation of the topoisomerase II-DNA cleavage complex. Thus, Berberubin is of value as a new anticancer agent targeting topoisomerase II. In addition, since berrubin has a mechanism of action different from that of the conventional topoisomerase II poison, it is expected to overcome drug resistance due to repeated use of conventional anticancer drugs. |
| priorityDate | 1998-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.