| abstract |
Phosphonate nucleotide compounds of Formula I, salts thereof, hydrates thereof and solvates thereof and pharmaceutical products containing them.n n n Formula In n n n n n n n In Formula I above,n n n R 1 is a C 1 to C 6 alkyl group,n n n R 2 is a hydrogen atom, a halogenated C 1 to C 4 alkyl group, or the like,n n n R 3 is a hydrogen atom, a halogenated C 1 to C 4 alkyl group, or the like,n n n R 4 is a hydrogen atom, a halogenated C 1 to C 4 alkyl group, or the like,n n n X is a carbon atom or a nitrogen atom.n n n The pharmaceutical products of the present invention are useful as antiviral agents against human immunodeficiency virus, herpes simplex virus, hepatitis B virus and the like, and also as antitumor agents. |