| abstract |
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, useful for the treatment of arthritis diseases, colorectal cancer and Alzheimer's disease.n n n Formula In n n n n n n n Wheren n n R 1 , R 2 , R 3 and R 4 are each independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aralkoxy, trifluoroalkoxy, alkanoyloxy, hydroxy, halo, trifluoromethyl, cya No, amino, mono- or di-alkylamino, alkanamido, or alkanesulfonamido,n n n R 5 is hydrogen, alkyl, alkenyl, alkoxyalkyl or alkylcycloalkyl,n n n R 6 is hydrogen, alkyl or alkenyl,n n n X is oxygen or carbon,n n n A is oxygen or NZ,n n n Z is hydroxyl, alkoxy, aryloxy, carboxyalkyloxy having 2 to 7 carbon atoms, arylamino or alkylsulfonylamino having 1 to 6 carbon atoms. |