| abstract |
The present invention relates to a depsi peptide or a pharmacologically acceptable salt thereof.n n n [Formula 1]n n n n n n n n [Wherein, R 1 represents a linear or branched alkyl group having 5 to 20 carbon atoms or a linear or branched alkoxymethyl group having 5 to 15 carbon atoms, and R 2 represents -AB, -ABW, -ABWD or -ABWDE R < 3> represents a hydroxyl group, a lower alkoxy group, a benzyloxy group, -Z, -ZG, -ZGJ, and said A, B, D, E, G, and J are respectively independently alanine, a varine, leucine, and iso Amino acid residues selected from leucine, serine, threonine, lysine, hydroxylysine, arginine, cysteine, methionine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamic acid and glutamine, or NC 1 to C 4 alkyl derivatives of these amino acid residues; W and Z each independently represent an amino acid residue consisting of aspartic acid, asparagine, glutamic acid, glutamine, alanine, serine or lysine.n n n The depsi peptide has an apolipoprotein E production promoting action, is useful as a drug for treating nerve damage, particularly as a drug for treating dementia, and also as a drug for treating hyperlipidemia. |