abstract |
Compounds of formula (I) are useful for the prevention and treatment of diseases caused by the destruction of connective tissue for inhibiting matrix metalloproteinase enzymes in animals.n n n <Formula I>n n n n n n n n Wheren n n R 1 comprises alkyl, halo, nitro, amino, cyano, alkoxy and alkoxycarbonyl;n n n R 2 is alkyl and substituted alkyl;n n n R 3 is OH or NHOH. |