| abstract |
The present invention provides a compound useful as a prophylactic and therapeutic agent for bone and cartilage patients and a pharmaceutical composition containing the same.n n n The present invention relates to polyhydroxyphenol derivatives represented by the following formula (I) and quinone analogs thereof.n n n <Formula 1>n n n n n n n n In the above formula, R 1 represents an alkyl group, a benzyl group which may be substituted or an aryl group which may be substituted, R 2 represents a hydrogen atom, an alkyl group, an alkenyl group or a benzyl group which may be substituted, and R 3 represents a hydrogen atom, an alkyl group or an alkenyl group , A substituted benzyl group, a hydroxyl group, an alkoxy group, an alkenyloxy group or a optionally substituted benzyloxy group, R 4 represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted benzyl group, or a hydroxyl group, R 5 and R 6 independently represent a hydrogen atom, an alkyl group, an alkenyl group, or each may be optionally substituted benzyl.n n n The hydroxyphenol derivatives and quinone analogs thereof of the present invention have strong bone absorption inhibitory activity and are useful as a prophylactic and therapeutic agent for bone and cartilage diseases. |