| abstract |
The present invention provides a novel compound of formula II, pharmaceutically acceptable salt thereof, enantiomer thereof, racemic mixture thereof and diastereomeric mixture thereof having antidiabetic and / or antihyperglycemic and / or antiobesity activity, and It provides a pharmaceutical composition thereof, a method of treatment using the compound and a method of preparing the compound.n n n Formula IIn n n n n n n n In the above formula,n n n R 1 and R 6 are independently hydrogen, C 1 -C 6 alkyl, trifluoromethyl, cyano, C 1 -C 6 alkoxy or halogen,n n n R 2 is hydrogen or C 1 -C 6 trialkylsilyl,n n n R 3 is hydrogen or C 1 -C 6 alkoxycarbonyln n n R 2 and R 3 are bonded together to formula (a) To form a ring where R 'is hydrogen, C 1 -C 6 alkyl or aryl,n n n R 4 and R 5 are independently hydrogen or C 1 -C 6 alkyl,n n n R 7 and R 8 are independently OR 9 or NR 10 R 11 ,n n n R 9 is hydrogen, C 1 -C 12 alkyl, C 1 -C 12 cycloalkyl, C 1 -C 12 silylalkyl, aryl, arylalkyl, alkoxyalkyl, heteroaryl, -CHR 12 COOR 13 , -CHR 12 C ( O) R 13 , -CHR 12 CONR 10 R 11 , -CHR 12 OCOOR 13 or -CHR 12 OC (O) R 13 , provided that R 9 is not hydrogen in both R 7 and R 8 ,n n n R 10 and R 11 are independently hydrogen, C 1 -C 12 alkyl, aralkyl, aryl, furanylalkyl or alkoxycarbonylalkyl,n n n R 12 and R 13 are independently hydrogen, C 1 -C 12 alkyl, aryl or aralkyl. |