| abstract |
The present invention relates to compounds of formula (I), which are useful for the treatment of diseases mediated by s-CD23.n n n <Formula I>n n n n n n n n In the above formula,n n n R is hydroxy, hydrogen, alkyl, alkenyl, alkynyl or aryl,n n n R 1 is arylmethyl or heterocyclylmethyl,n n n R 2 is alkyl, alkenyl, aryl, cycloalkyl or cycloalkenyl,n n n R 3 is hydrogen, alkyl, alkenyl, alkynyl or aryl,n n n Provided that R 1 is phenylmethyl or naphthylmethyl, wherein the phenyl or naphthyl group is unsubstituted, halogen, (C 1-6 ) alkyl, aryl (C 1-6 ) alkyl, (C 1-6 ) alkoxy, (C 1-6 ) alkoxy (C 1-6 ) alkyl, halo (C 1-6 ) alkyl, hydroxy, nitro, amino, mono-N- (C 1-6 ) alkylamino, di-N- (C 1-6) alkylamino, acylamino, acyloxy, carboxy, carboxy salts, carboxy esters, carbamoyl, mono -N- (C 1-6) alkyl carbamoyl, di -N- (C 1-6) Alkylcarbamoyl, (C 1-6 ) alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, sulfonylamino, aminosulfonyl, (C 1-6 ) alkylthio, (C 1-6 ) Alkylsulfinyl, (C 1-6 ) alkylsulfonyl, heterocyclyl, heterocyclyl (C 1-6 ) alkyl and two adjacent ring carbon atoms to form a carbocycle ring (C 3-5 Is substituted with up to 5 substituents selected from the group consisting of alkylene chains,n n n R is hydroxy. |