http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20000010866-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26d57cf7a0589bb8d93b0670dc174480 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-16 |
| filingDate | 1996-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c956efa7e07a0296b73e172083fbd5d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49e21938c744c81e6bbad6c2a8d2e5a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0c9ce4b4481ccc06f13ba77f851ad52 |
| publicationDate | 2000-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20000010866-A |
| titleOfInvention | Glycoprotein Hormone Superactive Drug |
| abstract | The present invention provides a human glycoprotein comprising at least one, two, three, four or five basic amino acids at positions selected from the group consisting of positions 11, 13, 14, 16, 17 and 20 of the α-subunit It's about hormones. The invention also relates to human glycoproteins wherein at least one of the amino acids at positions 58, 63 and 69 of the thyroid stimulating hormone β-subunit is a basic amino acid. In addition, the present invention has increased activity compared to wild-type human glycoprotein, comprising one basic amino acid substituted at the same position as in non-human glycoprotein hormone, which has increased activity over wild-type human glycoprotein hormone. To a modified human glycoprotein hormone. The invention also includes comparing the amino acid sequence of a more active homolog derived from another species to a human hormone; Replacing an amino acid of a human hormone with a corresponding amino acid of another species; Measuring the activity of the electrosubstituted human hormone; And selecting a superactive analogue from the electrosubstituted human hormones. The present invention also relates to a nucleic acid encoding an electrically modified human glycoprotein hormone, a vector comprising the electric nucleic acid, and a host cell comprising the electrical vector. |
| priorityDate | 1998-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 293.