| abstract |
The present invention is directed to pathogenic E. coli such as enteropathogenic (EPEC) E. coli. Coli and Enterohemorrhagic (EHEC) E. Provided are EspA polypeptides secreted by E. coli. Such pathogenicity. Diseases caused by coli can be diagnosed through standard techniques, such as methods based on the use of antibodies that bind EspA to detect proteins and the use of nucleic acid probes to detect nucleic acids encoding EspA proteins. The invention also provides isolated nucleic acid sequences encoding EspA, EspA polypeptides, EspA peptides, methods of producing recombinant EspA, antibodies that bind EspA, and E. Provided are kits for detecting collie. The present invention also provides a method of immunizing a host with EspA to induce a prophylactic immune response against EspA. |