| abstract |
The present invention relates to a pharmaceutically useful peptide derivative represented by the following formula (I), a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same,n n n Formula In n n n n n n n Wherein P, R 1 , R 2 , R 3 and R 4 are as described herein. The novel peptide derivatives are effective in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases such as rheumatoid arthritis. The present invention also relates to methods of preparing novel peptide derivatives and their use in pharmaceutical therapy. |