http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990080246-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-703 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 |
| filingDate | 1998-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990080246-A |
| titleOfInvention | Acquired immunodeficiency virus-1 type O antigen and preparation method thereof |
| abstract | The present invention relates to HIV-1 type O specific antigen proteins derived from genes encoding the extracellular domain of HIV-1 type Gp41 protein and useful as diagnostic agents for HIV-1 type O infection. The present inventors cloned genes of various sizes encoding parts of the extracellular domain of Gp41 protein from the sera of humans infected with HIV-1 type O, and expressed a large amount of the protein derived therefrom in E. coli. When the 387 bp gene fragment encoding the amino acid 659 region of the amino acid 531 according to the Vanden Haesevelde numbering system in the extracellular region of the protein was cloned, it was confirmed that the antigen protein was most efficiently expressed. In addition, the antigenic protein was isolated and purified to confirm that the antigenic protein of the present invention has high antigen-antibody reactivity and specificity by immunological test. Commercial ELISA kits that use existing HIV-1 type B antigens also react with the serum of HIV-1 type O infections, but have low specificity and sensitivity. Of serum was highly likely to be false negative. Therefore, it is expected that the detection efficiency and accuracy of HIV-infected serum can be maximized by adding the HIV-1 O Gp41 antigen of the present invention to the existing HIV diagnostic reagent. |
| priorityDate | 1998-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.