http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990075382-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-00 |
| filingDate | 1998-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990075382-A |
| titleOfInvention | Inhibition of Cholesterol Biosynthesis Using Macrolactin-A Produced in Streptomyces Fish Y-401 |
| abstract | The present invention relates to a method for inhibiting cholesterol biosynthesis using macrolactin A. More specifically, the present invention relates to a method for inhibiting cholesterol biosynthesis using macrolactin A, which inhibits the activity of squalene synthase, which is a rate controlling step in the in vivo cholesterol biosynthesis process. Since macrolactin A has activity that inhibits squalene synthase in a concentration-dependent manner, inhibiting cholesterol biosynthesis with macrolactin A promotes the synthesis of low density lipoprotein-cholesterol receptors in cells. Eventually, the level of cholesterol in the blood is lowered. In addition, macrolactin A may be developed as a medicament in earnest by clinical trials and the like, and may be used as a preventive and therapeutic agent for cardiovascular diseases such as atherosclerosis and coronary artery disease. |
| priorityDate | 1998-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.