| abstract |
The present invention relates to compounds represented by the following formula (1), pharmaceutically acceptable prodrugs, salts and solvates thereof:n n n (One)n n n In the above formula (1), Z is oxygen or sulfur; V is a divalent radical which forms a ring consisting of C * and nitrogen and 6 atoms in which the atoms except C * and nitrogen are unsubstituted or substituted by suitable substituents and at least one atom Is a heteroatom selected from oxygen, nitrogen and sulfur and the remaining atoms are carbon atoms; And Ar is an aryl or heteroaryl group. The present invention also relates to a method for inhibiting the activity of a metalloproteinase by administering a compound represented by the above formula (1), a prodrug, a salt or a solvate thereof. The present invention also relates to a pharmaceutical composition comprising an effective amount of the compound, a prodrug thereof, a salt, and a solvate. The present invention also relates to intermediates useful in preparing the above compounds, prodrugs, salts, and solvates thereof. |