http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990071598-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 |
| filingDate | 1996-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990071598-A |
| titleOfInvention | Quinoline-4-carboxamide derivative, its preparation method and its use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonist |
| abstract | The present invention provides compounds of formula (I), salts or solvates thereof.n n n (I)n n n n n n n n Wherein,n n n Ar is optionally substituted aryl or C 5-7 cycloalkyl group Al keudi, or an optionally substituted single or fused ring aromatic heterocyclic group;n n n R is phenyl optionally substituted with up to four heteroatoms selected from C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylalkyl, optionally substituted phenyl or phenyl C 1-6 alkyl, O and N a 5-membered heteroaromatic ring, hydroxy groping C 1-6 alkyl, amino C 1-6 alkyl, C 1-6 alkylamino-alkyl, di-C 1-6 alkylaminoalkyl, C 1-6 acylamino-alkyl, C 1 -6 alkoxyalkyl, C 1-6 alkylcarbonyl, carboxy, C 1-6 alkoxycarbonyl, C 1-6 alkoxycarbonyl C 1-6 alkyl, aminocarbonyl, C 1-6 alkylamino-carbonyl, di C 1-6 alkylaminocarbonyl or halogenoC 1-6 alkyl; R is a group - (CH 2 ) p - (where p is 2 or 3) which forms a ring with the carbon atom of Ar;n n n R 1 is hydrogen, C 1-6 alkyl, C 1-6 alkenyl, aryl, C 1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamide not shown, sulfone amido, C 1- 4 or 6 optional substituents selected from the group consisting of alkoxycarbonyl, trifluoromethyl, acyloxy, phthalimido, amino or mono- and di-C 1-6 alkylamino;n n n R 2 is hydrogen, C 1-6 - alkyl, hydroxy, halogen, cyano, amino, mono- or di -C 1-6 alkylamino, alkylsulfonylamino, mono- or di -C 1-6 alkanoyl Wherein any alkyl group is optionally substituted with an amino group or a mono- or di-alkylamino group, or R 2 is a residue -X- (CH 2 ) n -Y where X is a bond or -O- and n is an integer from 1 to 5 range, provided that in when X is -O- n is only an integer from 2 to 5, Y is a group NY 1 Y 2, Y 1 and Y 2 is hydrogen, C 1-6 Alkyl, C 1-6 alkenyl, aryl or aryl-C 1-6 -alkyl, or Y is hydroxy, halogen or an optionally substituted N-linked single or fused ring or heterocyclic group ;n n n R 3 is branched or linear C 1-6 alkyl, C 3-7 cycloalkyl, C 4-7 cycloalkylalkyl, optionally substituted aryl, or an optionally substituted single or fused ring aromatic heterocyclic group;n n n R 4 represents hydrogen or C 1-6 alkyl. |
| priorityDate | 1995-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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