http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990071520-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1996-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990071520-A |
| titleOfInvention | Pyrido [2,3-D] pyrimidine derivatives and pharmaceutical compositions thereof |
| abstract | The present invention has the effect of inhibiting the activity of type IV phosphodiesterase and is useful as a medicament, particularly as a phosphodiesterase inhibitor of type IV, or as a medicament for the prevention of diseases associated with promotion of antinastiant type IV PDE activity, particularly respiratory diseases such as bronchial asthma And a compound of formula (I) or a pharmaceutically acceptable salt thereof useful as a therapeutic agent.n n n Formula In n n n n n n n In this formula,n n n X is oxygen or sulfur,n n n R < 1> is lower alkyl, cycloalkyl (lower alkyl) or cycloalkyl,n n n R 2 is hydrogen, halogeno, lower alkyl, halo (lower alkyl), hydroxy (lower alkyl), mercapto (lower alkyl), (lower alkoxy) (lower alkyl), (lower alkylthio) (Lower alkyl), (lower alkanoylthio) (lower alkyl), (lower alkanoyl) (lower alkyl), hydroxyimino (lower alkyl), (lower alkoxyimino) Cycloalkyl, aryl or lower alkanoyl,n n n R < 3 > is hydrogen, halogeno or lower alkyl,n n n R < 4 > is hydrogen or lower alkyl,n n n R 5 is cycloalkyl which may be substituted with the same group of R 6 ; Naphthyl optionally substituted with the same group of R < 6 & gt ;; A 5- or 6-membered monocyclic heterocycle optionally substituted with the same group of R < 6 > and having 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, optionally fused with a benzene ring; Or < Lt; / RTI >n n n R 6 is halogeno, lower alkyl, halo (lower alkyl), hydroxy, lower alkoxy, cyano or nitro a furnace. |
| priorityDate | 1995-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 498.