http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990063891-A
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
filingDate | 1996-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 1999-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | KR-19990063891-A |
titleOfInvention | (Imidazol-5-yl) methyl-2-quinolinone derivatives with farnesyl protein transferase inhibitory function |
abstract | The present invention relates to a compound of formula (I) having farnesyl transferase inhibitory activity, a preparation method thereof, a composition containing them and a medicament containing them as a medicament.n n n <Formula I>n n n n n n n n Wherein the dotted line optionally represents a bond; X is oxygen or sulfur; R 1 is hydrogen, C 1-12 alkyl, Ar 1, Ar 2 C 1-6 alkyl, quinolinyl C 1-6 alkyl, pyridyl C 1-6 alkyl, hydroxy C 1-6 alkyl, C 1- 6 alkyloxyC 1-6 alkyl, mono- or di (C 1-6 alkyl) aminoC 1-6 alkyl, aminoC 1-6 alkyl, or the formula —Alk 1 -C (═O) —R 9 , -Is a radical of -Alk 1 -S (O) -R 9 or -Alk 1 -S (= 0) 2 -R 9 ; R 2 , R 3 and R 16 are each independently hydrogen, hydroxy, halo, cyano, C 1-6 alkyl, C 1-6 alkyloxy, hydroxyC 1-6 alkyloxy, C 1-6 alkyloxy C 1-6 alkyloxy, aminoC 1-6 alkyloxy, mono- or di (C 1-6 alkyl) aminoC 1-6 alkyloxy, Ar 1 , Ar 2 C 1-6 alkyl, Ar 2 oxy, Ar 2 C 1-6 alkyloxy, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C 2-6 alkenyl; R 4 and R 5 are each independently hydrogen, halo, Ar 1 , C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylthio, amino, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyl S (O) C 1-6 alkyl or C 1-6 alkyl S (O) 2 C 1- 6 alkyl; R 6 and R 7 are each independently hydrogen, halo, cyano, C 1-6 alkyl, 4,4-dimethyloxazolyl, C 1-6 alkyloxy or Ar 2 oxy; R 8 is hydrogen, C 1-6 alkyl, cyano, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonylC 1-6 alkyl, cyanoC 1-6 alkyl, C 1-6 alkyloxycarbonylC 1-6 alkyl, carboxyC 1-6 alkyl, hydroxyC 1-6 alkyl, aminoC 1-6 alkyl, mono- or di (C 1-6 alkyl) aminoC 1- 6 alkyl, imidazolyl, haloC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, aminocarbonylC 1-6 alkyl, formula -OR 10 , -SR 10 , or -NR 11 R 12 Forms a radical of; R 17 is hydrogen, halo, cyano, C 1-6 alkyl, C 1-6 alkyloxycarbonyl, or Ar 1 ; R 18 is hydrogen, C 1-6 alkyl, C 1-6 alkyloxy or halo; R 19 is hydrogen, C 1-6 alkyl. |
priorityDate | 1995-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 287.