http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990062800-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 |
| filingDate | 1998-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990062800-A |
| titleOfInvention | 1,3,8-triaza-spiro [4,5] decan-4-one derivatives |
| abstract | The present invention relates to compounds of formula (1) and pharmaceutically acceptable acid addition salts thereof:n n n n n n n n n n In the above formula,n n n R 1 is hydrogen, lower alkyl, halogen, lower alkoxy, trifluoromethyl, lower alkyl-phenyl or (C 5-7 ) -cycloalkyl;n n n R 2 is hydrogen, lower alkyl, phenyl or lower alkyl-phenyl;n n n R 3 is hydrogen, lower alkyl, benzyl, lower alkyl-phenyl, lower alkyl-diphenyl, triazinyl, cyanomethyl, lower alkyl-piperidinyl, lower alkyl-naphthyl, (C 5-7 ) -cycloalkyl , Lower alkyl- (C 5-7 ) -cycloalkyl, lower alkyl-pyridinyl, lower alkyl-morpholinyl, lower alkyl-dioxolanyl, lower alkyl-oxazolyl or lower alkyl-2-oxo-oxazolidinyl Wherein the ring system is further lower alkyl, lower alkoxy, trifluoromethyl or phenyl, or-(CH 2 ) n C (O) O-lower alkyl,-(CH 2 ) n C (O) NH 2 ,-(CH 2 ) n C (O) N (lower alkyl) 2 ,-(CH 2 ) n OH or-(CH 2 ) n C (O) NHCH 2 C 6 H 5 ;n n n R 4 is hydrogen, lower alkyl or nitrile;n n n A may be optionally substituted with (a) lower alkyl, trifluoromethyl, phenyl, (C 5-7 ) -cycloalkyl, spiro-undecane-alkyl or 2-norbornyl in addition to R 4 (C 5-15 Or (b) a group of formula (2), (c) a group of formula (3), (d) a group of formula (4), (e) dodecahydro-acenaphthylene-1 -Day, (f) bicyclo [6.2.0] deck-9-yl and (g) bicyclononan-9-yl:n n n n n n n n n n n n n n n n n n n n n n n n In the above formula,n n n R 5 and R 6 are hydrogen, lower alkyl or together with the carbon atom to which they are attached form a phenyl ring;n n n R 7 is hydrogen or lower alkyl;n n n The dotted line represents any bond;n n n n is 1-4.n n n Compounds of the invention are agonists and / or antagonists of orphanin FQ (OFQ) receptors. As a result, they are useful in the treatment of memory and attention deficits, mental illness, neurological and physiological diseases, especially memory loss due to anxiety and stress symptoms, depression, shock, Alzheimer's disease or other dementia, epilepsy and convulsions, acute And / or useful for, but not limited to, improving metabolic abnormalities such as chronic pain disease, addictive drug withdrawal symptoms, control of equilibrium, Na + secretion, arterial blood pressure disease, and obesity. |
| priorityDate | 1997-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 481.