http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990062599-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1998-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990062599-A |
| titleOfInvention | Cefem derivatives and preparation methods thereof and antimicrobial compositions containing the same |
| abstract | The compound of the present invention relates to a cefe derivative compound of formula (I) or a pharmacologically acceptable salt or hydrate thereof, which is effective for both Gram-positive bacteria and Gram-positive bacteria, as well as Gram-negative bacteria, and exhibits excellent antimicrobial activity. :n n n Formula (I)n n n In the above formula,n n n X is i) an amine or a protected amine group, or ii) Wherein Y is i) hydrogen, ii) chlorine, fluorine, cyano, nitro, hydroxy, amino, C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino, hydroxylamino , C 1 -C 4 alkoxyamino, C 1 -C 4 alkoxyimino, C 1 -C 4 alkoxy, C 1 -C 4 acyloxy, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulphenyl, C 1 ~ C 4 alkyl sulfinyl, C 1 ~ C 4 alkyl, amino-sulfonyl, carboxyl, and or unsubstituted substituted by one or more substituents selected from the group consisting of his inorganic cationic salt C 1 ~ C 6 lower Alkyl, iii) chlorine, fluorine, cyano, nitro, hydroxy, amino, C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino, hydroxylamino, C 1 -C 4 alkoxyamino, C 1- C 4 alkoxyimino, C 1 ~ C 4 alkoxy, C 1 ~ C 4 acyloxy, C 1 ~ C 4 alkylsulfonyl, C 1 ~ C 4 alkyl sulfonic phenyl, C 1 ~ C 4 alkyl sulfinyl, C 1 ~ C 4 alkylaminosulfonyl, carboxylic acid and inorganic cations thereof C 2 -C 6 alkenyl substituted or unsubstituted by one or more substituents selected from the group consisting of iv) chlorine, fluorine, cyano, nitro, hydroxy, amino, C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino, hydroxylamino, C 1 -C 4 alkoxyamino, C 1 -C 4 alkoxyimino, C 1 -C 4 alkoxy, C 1 -C 4 acyloxy, C 1 -C 4 alkyl by sulfonyl, C 1 ~ C 4 alkyl sulfonic phenyl, C 1 ~ C 4 alkyl sulfinyl, C 1 ~ C 4 alkyl aminosulfonyl, carboxylic acids and one or more substituents selected from the group consisting of his inorganic cation salt Substituted or unsubstituted C 2 to C 6 alkynyl, v) chlorine, fluorine, cyano, nitro, hydroxy, amino, C 1 to C 4 alkylamino, C 1 to C 4 dialkylamino, hydroxylamino , C 1 -C 4 alkoxyamino, C 1 -C 4 alkoxyimino, C 1 -C 4 alkoxy, C 1 -C 4 acyloxy, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulphenyl, C 1 ~ C 4 alkylsulfinyl, C 1 ~ C 4 Phenyl substituted or unsubstituted by one or more substituents selected from the group consisting of alkylaminosulfonyl, carboxylic acid and inorganic cation salts thereof, vi) R 4-(CH 2 ) n-wherein n is 0 to 3 and integer, R4 is chlorine, fluorine, hydroxy, amino, C 1 ~ C 4 alkyl, C 1 ~ C 4 acylamino, C 1 ~ C 4 alkyl sulfonylamino, C 1 ~ C 4 alkoxy and C 1 ~ 2-thiophenyl, 2-furyl, 2-pyrrolyl, 4-thiazolyl, 1,2,4-thiadiazol-3-yl, substituted by one or more substituents selected from the group consisting of C 4 acyloxy, 2-oxazolyl derivatives or 5- or 6-membered heterocyclic compounds having 1 to 4 atoms of O, S and N atoms), vii) Wherein Z is hydrogen or chlorine, fluorine, cyano, nitro, hydroxy, amino, C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino, hydroxylamino, C 1 -C 4 alkoxyamino, C 1 -C 4 alkoxyimino, C 1 -C 4 alkoxy, C 1 -C 4 acyloxy, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulphenyl, C 1 -C 4 alkylsulfinyl, C 1 ~ C 4 alkyl, amino-sulfonyl, carboxyl, and or unsubstituted substituted by one or more substituents selected from the group consisting of his inorganic cationic salt C 1 ~ C 6 lower alkyl, C 1 ~ C 6 alkenyl , C 2 ~ C 6 alkynyl, phenyl or heterocyclic compound, the optically active carbon may have optically pure (-), (+) and racemic),n n n viii) Wherein W is CH or N, R 1 is hydrogen, lower alkyl substituted with lower alkyl, carboxy or inorganic cation salt thereof or lower alkyl substituted with protected carboxy, the alkoxy imino is syn isomer;n n n R 2 is independently hydrogen, fluorine, chlorine or methoxy;n n n R 3 is hydrogen or lower alkyl substituted with lower alkyl, carboxy or an inorganic cation salt thereof, lower alkyl substituted with amino or lower alkyl substituted with alkoxy;n n n Provided that the phenyloxazolidinone substituent in the compound of formula (I) is substituted at position 3 or 4 of the pyridine ring. The present invention also relates to a process for preparing the above compound of formula (I). The present invention also relates to an antimicrobial composition containing the compound of formula (I). |
| priorityDate | 1997-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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