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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-727
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
filingDate 1997-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1999-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-19990047907-A
titleOfInvention A culture method for increasing the production amount of recombinant protein using a medium supplemented with novobiocin
abstract The present invention relates to a method for increasing the production of recombinant protein using a medium supplemented with novobiocin as a cell cycle inhibitor in the production of recombinant proteins through animal cell culture, and more particularly, A method of increasing the amount of recombinant protein per unit cell by replacing the cells with a medium supplemented with nobiobiocin, which is a substance that sufficiently inhibits cell proliferation and induces protein expression, . When the animal cells producing the recombinant protein are cultured by the method of the present invention, the production amount of the recombinant protein can be increased by at least 4 times.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20050070512-A
priorityDate 1997-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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