http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990045206-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-027 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-34 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B10-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B67-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-20 |
| filingDate | 1998-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990045206-A |
| titleOfInvention | In vivo coloring compositions, manufacturing processes and methods for identifying dysplasia tissues |
| abstract | The present invention relates to the synthesis, separation and identification of N-demethylated and N, N-demethylated derivatives of two conformational isomers of toluidine blue O (“TBO”).n n n In vivo biocolored compositions include morphic isomers of TBO and their N- and N, N-demethylated derivatives. The ratio of these isomers to these demethylated derivatives is at least 6: 1.n n n Improved methods for detecting underdeveloped oral tissue include applying such TBO product to oral tissue with a liquid carrier.n n n The process for producing the TBO product comprises the steps of (1) oxidizing N, N-dimethyl-ρ-phenylenediamine with, for example, potassium dichromate to form 2-amino-5-dimethylaminophenyl thiosulfonic acid, (2) Oxidizing this intermediate, condensing the oxide with o-toluidine to form indaminthiosulfonic acid, and (3) further oxidizing the indamin intermediate to form a TBO containing reaction product, which precipitates from the reaction mixture as a complex. And separating the final TBO product therefrom. The complexing agent is added to the reaction mixture at least before the final oxidation step, preferably before the second oxidation step.n n n HPLC methods characterize TBO products containing form isomers of TBO and their N, N-demethylated derivatives. The mobile phase comprises an aqueous solution of an organic acid compound. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100905628-B1 |
| priorityDate | 1997-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.